General Information

  • ID:  hor004394
  • Uniprot ID:  P20366
  • Protein name:  Substance P
  • Gene name:  TAC1
  • Organism:  Homo sapiens (Human)
  • Family:  Tachykinin family
  • Source:  Human
  • Expression:  NA
  • Disease:  Diseases associated with TAC1 include Vasomotor Rhinitis and Cystitis.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0031835 substance P receptor binding
  • GO BP:  GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007320 insemination; GO:0009582 detection of abiotic stimulus; GO:0019233 sensory perception of pain; GO:0048265 response to pain; GO:1990090 cellular response to nerve growth factor stimulus
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon; GO:0043025 neuronal cell body; GO:0045202 synapse

Sequence Information

  • Sequence:  RPKPQQFFGLM
  • Length:  11
  • Propeptide:  MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRR
  • Signal peptide:  MKILVALAVFFLVSTQLFA
  • Modification:  T11 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Possesses direct antimicrobial activity, highest against S. aureus
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  TACR1, TACR2
  • Target Unid:  P25103, P21452
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 2.1 (t1/2 of hydrolysis) minutes; /126 seconds ( PubMed ID: 7529108 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P20366-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004394_AF2.pdbhor004394_ESM.pdb

Physical Information

Mass: 152717 Formula: C63H97N17O14S
Absent amino acids: ACDEHINSTVWY Common amino acids: FPQ
pI: 11.65 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -70 Boman Index: -1738
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 35.45
Instability Index: 4790.91 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12074933##7529108
  • Title:  Direct Antimicrobial Properties of Substance P